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A Life Course Perspective on Diabetes: Developmental Origins and Beyond

Cover of Developmental Origins issue

Type 2 diabetes, once considered a disease of old age, sadly now occurs not uncommonly in children and young adults. Diabetes thus affects everyone, from cradle to grave, and thus we have chosen ‘A life course perspective on diabetes: developmental origins and beyond’ as the theme of our 2019 special issue. The issue covers evolution and the diabesity epidemic, racial and sex differences in the burden of type 2 diabetes, under- and overnutrition and obesity/diabetes risk, maternal and paternal in utero programming, environmental agents as diabetes risk factors, the impact of early-life factors on type 1 diabetes, and cellular senescence and ageing effects in diabetes. We conclude with a piece tackling the question: what should governments do?

 

To watch an interview with Professor Dana Dabelea talking about this issue, click here.

A life course perspective on diabetes: developmental origins and beyond

Sally M. Marshall
Fig from Wells paper

The diabesity epidemic in the light of evolution: insights from the capacity–load model

Jonathan C. K. Wells
Fig from Hill Golden paper

Racial/ethnic differences in the burden of type 2 diabetes over the life course: a focus on the USA and India

Sherita H. Golden, Chittaranjan Yajnik, Sanat Phatak, Robert L. Hanson and William C. Knowler
Sex differences in the burden of type 2 diabetes and cardiovascular risk across the life course

Sex differences in the burden of type 2 diabetes and cardiovascular risk across the life course

Amy G. Huebschmann, Rachel R. Huxley, Wendy M. Kohrt, Philip Zeitler, Judith G. Regensteiner and Jane E. B. Reusch
Developmental undernutrition, offspring obesity and type 2 diabetes

Developmental undernutrition, offspring obesity and type 2 diabetes

Aryeh D. Stein, Okezi E. Obrutu, Rishikesh V. Behere and Chittaranjan S. Yajnik
Fig from Perng paper

Developmental overnutrition and obesity and type 2 diabetes in offspring

Wei Perng, Emily Oken and Dana Dabelea
Figure from Fernandez-Twinn paper

Intrauterine programming of obesity and type 2 diabetes

Denise S. Fernandez-Twinn, Line Hjort, Boris Novakovic, Susan E. Ozanne and Richard Saffery
Fig from Sharp paper

Paternal impact on the life course development of obesity and type 2 diabetes in the offspring

Gemma C. Sharp and Debbie A. Lawlor
Figure from Sargis paper

Environmental neglect: endocrine disruptors as underappreciated but potentially modifiable diabetes risk factors

Robert M. Sargis and Rebecca A. Simmons
Early-life factors contributing to type 1 diabetes

Early-life factors contributing to type 1 diabetes

Maria E. Craig, Ki Wook Kim, Sonia R. Isaacs, Megan A. Penno, Emma E. Hamilton-Williams, Jennifer J. Couper and William D. Rawlinson
Fig from Palmer paper

Cellular senescence: at the nexus between ageing and diabetes

Allyson K. Palmer, Birgit Gustafson, James L. Kirkland and Ulf Smith
What should governments be doing to prevent diabetes throughout the life course?

What should governments be doing to prevent diabetes throughout the life course?

Patrick Timpel, Lorenz Harst, Doreen Reifegerste, Susann Weihrauch-Blüher and Peter E. H. Schwarz
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