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Advances and challenges in measuring hepatic glucose uptake with FDG PET: implications for diabetes research – published online 15/12/2023

Basset-Sagarminaga graphical abstract

Jeremy Basset‑Sagarminaga, Tineke van de Weijer, Patricia Iozzo, Patrick Schrauwen, Vera Schrauwen‑Hinderling

The liver, a pivotal organ in maintaining glucose balance, has emerged as a focal point in the quest to understand the pathogenesis of type 2 diabetes. Hepatic glucose uptake (HGU), a critical aspect of liver metabolism, can be measured using positron emission tomography (PET), but there are unique challenges related to the physiology and metabolic complexity of the liver. In this issue, Basset-Sagarminaga et al (https://doi.org/10.1007/s00125-023-06055-7) provide a comprehensive perspective on the array of protocols available for the measurement of HGU using [18F]-2-fluoro-2-deoxy-d-glucose (FDG) PET and delve into the current state of knowledge concerning HGU and its dysregulation in the context of type 2 diabetes. The authors conclude that FDG PET techniques hold the potential to reshape our understanding of metabolic diseases and advance therapeutic strategies. The figures from this review are available as a downloadable slideset

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