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Association of early-onset diabetes, prediabetes and early glycaemic recovery with the risk of all-cause and cardiovascular mortality – published online 21/08/2020

Sung Min Kim, Gyeongsil Lee, Seulggie Choi, Kyuwoong Kim, Su-Min Jeong, Joung Sik Son, Jae-Moon Yun, Sin Gon Kim, Seung-sik Hwang, Seong Yong Park, Yeon-Yong Kim, Sang Min Park 

Recently, the increasing incidence of diabetes among young adults aged 20-30 years has added to the overall disease burden. Individuals with early-onset diabetes have similar or higher cardiovascular risk than those with late-onset diabetes.  In this issue, Kim and Lee and colleagues (https://doi.org/10.1007/s00125-020-05252-y) investigated whether newly diagnosed early-onset diabetes, prediabetes and glycaemic recovery among young adults is associated with incident cardiovascular disease or mortality using data from a nationwide cohort study of 2,502,375 young adults without cardiovascular disease at baseline. They report that individuals with early-onset diabetes and prediabetes had increased risks of incident CVD and all-cause mortality at the 10 year follow up. Notably, in individuals with early glycaemic recovery from diabetes or prediabetes, the risks of incident 10-year CVD and all-cause or CVD mortality were reduced. The authors conclude that maintenance of glycaemic control in young adults may be important for the prevention of CVD and all-cause mortality

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