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Chrono-nutrition for the prevention and treatment of obesity and type 2 diabetes: from mice to men – published online 06/08/2020

John A. Hawley, Paolo Sassone-Corsi, Juleen R. Zierath

In the current ‘obesogenic’ environment there is growing popular and scientific interest in how the timing and frequency of meals impacts metabolic health, with an appreciation that the duration of which food is consumed effects numerous physiological and metabolic processes. Such ‘chrono-nutrition’ is aimed at optimising metabolism by timing nutrient intake to the acrophases of daily metabolic rhythms via manipulation of the feeding–fasting cycle. In this issue, Hawley and colleagues ( review recent research from both animal and human studies demonstrating that dietary protocols incorporating chronic energy restriction, intermittent fasting and time-restricted feeding improve multiple cardiometabolic markers associated with obesity and type 2 diabetes risk. The figure in this review is available as a downloadable slide.

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