Clonal haematopoiesis of indeterminate potential: an emerging risk factor for type 2 diabetes and related complications – published online 10/03/2025

María A. Zuriaga, José J. Fuster

Somatic mutations accumulate with age, but their effects beyond cancer are only beginning to be understood. Clonal haematopoiesis of indeterminate potential (CHIP), a type of clonal haematopoiesis driven by acquired mutations in genes associated with myeloid malignancies, has been linked to an increased risk of age-related conditions, particularly CVD. In this issue, Zuriaga and Fuster (https://doi.org/10.1007/s00125-025-06393-8) summarise emerging genetic and experimental evidence suggesting that CHIP may also contribute to the pathogenesis of type 2 diabetes and its complications, potentially through inflammatory mechanisms. The authors conclude that understanding the impact of CHIP on type 2 diabetes could open new avenues for risk stratification and targeted prevention strategies, but further studies are needed to clarify the mechanistic links and clinical implications of this association. The figures from this review are available as a downloadable slideset.