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Diabetes prevention and treatment: a global perspective

Special issue 2025 cover showing individuals from different parts of the globe facing various opportunities (examples in yellow boxes) and challenges (purple boxes) for the prevention and treatment of diabetes. The challenges are represented as broken rungs on a ladder, which make it very difficult to reach the intended health targets. The map is divided into areas based on the IDF’s regional groups.

Currently, global differences in diabetes epidemiology and pathophysiology and disparities in diabetes prevention and management are not well understood. We commissioned a series of reviews on this theme addressing topics from the importance of including diverse populations in diabetes research (Chaturvedi and Voight et al, https://doi.org/10.1007/s00125-025-06516-1) to global differences in the prevalence of diabetes types (e.g. type 2 diabetes, hyperglycaemia in pregnancy and monogenic diabetes [Gong et al, https://doi.org/10.1007/s00125-025-06478-4; Yuen et al, https://doi.org/10.1007/s00125-025-06510-7; Russ-Silsby et al, https://doi.org/10.1007/s00125-025-06495-3), metabolic disorders (Boddu et al, https://doi.org/10.1007/s00125-025-06450-2) and the development of complications (Luk et al, https://doi.org/10.1007/s00125-025-06482-8), the challenges of diabetes prevention in migrant populations and the Arctic Inuit (Bennet and Agyemang, https://doi.org/10.1007/s00125-025-06465-9; Nielsen et al, https://doi.org/10.1007/s00125-025-06487-3), global disparities in access to diabetes technologies and therapeutics (Addala et al, https://doi.org/10.1007/s00125-025-06494-4), and the relevance of ancestral and/or ethnic diversity in precision medicine (Shivani Misra, https://doi.org/10.1007/s00125-025-06513-4). In addition, we include a review on diabetes management in man-made and natural disasters (Boulton and Jenkins et al, https://doi.org/10.1007/s00125-025-06406-6), and the EASD Global Council calls for a coordinated global approach to diabetes research and care to promote equitable healthcare for all (Giorgino et al, https://doi.org/10.1007/s00125-025-06504-5). Most importantly, we have also included the diverse lived experiences of individuals with diabetes across the globe in this special issue to provide a more complete and inclusive understanding of the opportunities and challenges and highlight the importance of recognising the impact of diabetes on individuals from different backgrounds (Mytkolli et al, https://doi.org/10.1007/s00125-025-06506-3). This series of reviews is accompanied by an editorial by Herder et al (https://doi.org/10.1007/s00125-025-06511-6).

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