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Effects of continuous glucose monitor-recorded nocturnal hypoglycaemia on quality of life and mood during daily life in type 1 diabetes – published online 14/01/2021

henrikson graphical abstract

Marie M. Henriksen, Henrik U. Andersen, Birger Thorsteinsson, Ulrik Pedersen-Bjergaard

Symptomatic hypoglycaemia has been reported to reduce quality of life in type 1 diabetes; however, it remains unclear if nocturnal hypoglycaemia (recorded by continuous glucose monitoring [CGM]) affects daily reported quality of life. In this issue, Henriksen et al (https://doi.org/10.1007/s00125-020-05360-9) investigate the impact of CGM-recorded nocturnal hypoglycaemia on quality of life the following day in people with type 1 diabetes. The authors report that, in individuals with hypoglycaemia unawareness, who generally report lower quality of life, unrecognised nocturnal asymptomatic hypoglycaemia was associated with improved self-estimated quality of life the subsequent day (as assessed by the EuroQol-5D visual analogue scale [EQ-5D VAS] but not the WHO Well-Being Index) . The authors suggest that this may be driven by a different biological brain response to hypoglycaemia in people with hypoglycaemia unawareness, in accordance with patterns reported by previous neuroimaging studies. They state that these findings may help to explain differences in perception and attitudes towards hypoglycaemia among people with type 1 diabetes and emphasise the need for reducing the risk of both symptomatic and asymptomatic nocturnal hypoglycaemia.

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