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Epigenome-wide association study of incident type 2 diabetes: a meta-analysis of five prospective European cohorts – published online 15/02/2022

Fraszczyk graphical abstract

Eliza Fraszczyk, Annemieke M. W. Spijkerman, Yan Zhang, Stefan Brandmaier, Felix R. Day, Li Zhou, Paul Wackers, Martijn E. T. Dollé, Vincent W. Bloks, Xīn Gào, Christian Gieger, Jaspal Kooner, Jennifer Kriebel, H. Susan J. Picavet, Wolfgang Rathmann, Ben Schöttker, Marie Loh, W. M. Monique Verschuren, Jana V. van Vliet-Ostaptchouk, Nicholas J. Wareham, John C. Chambers, Ken K. Ong, Harald Grallert, Hermann Brenner, Mirjam Luijten, Harold Snieder

Epigenetics may play a role in the development of type 2 diabetes, and predictive DNA methylation markers have been identified in single-cohort epigenome-wide association studies. Combining results from several prospective cohorts may identify additional markers. In this issue, Fraszczyk et al (https://doi.org/10.1007/s00125-022-05652-2) report 76 DNA methylation markers from the meta-analysis of five European cohorts, of which 63 were novel for incident type 2 diabetes. The authors suggest that epigenetics has the potential to elucidate new biological pathways underlying the development of type 2 diabetes, and predictive DNA methylation markers could ultimately be useful in type 2 diabetes prevention efforts.

 

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