GIP contributes to postprandial regulation of splanchnic blood supply in humans with type 2 diabetes: a randomised, single‑blinded, placebo‑controlled, crossover study – published online 02/07/2026

Rasmus S. Rasmussen, Sophie W. Nielsen, Lotte Alstrup, Tanne S. W. Larsson, Jonathan K. Hansen, Rune P. Pedersen, Mark B. Vestergaard, Bryan Haddock, Helle H. Johannesen, Henrik B. W. Larsson, Jens J. Holst, Bolette Hartmann, Mette M. Rosenkilde, Ali Asmar, Ulrik B. Andersen, Lærke S. Gasbjerg

Over the last decade, medicine has revolutionised the treatment of individuals living with obesity and type 2 diabetes. The development of increasingly effective therapies has expanded interest to additional endocrine targets, including signalling through the glucose-dependent insulinotropic polypeptide (GIP) receptor. In this issue, Rasmussen et al (https://doi.org/10.1007/s00125-026-06788-1) investigate the effect of endogenous GIP on splanchnic blood flow in individuals with type 2 diabetes. Although the glucometabolic actions of exogenous GIP are known to be markedly attenuated or absent in this population, the authors demonstrate, using advanced MRI techniques, that endogenous GIP-mediated regulation of splanchnic circulation appears to be preserved. The authors conclude that, by providing novel insights into GIP physiology, this study improves our understanding of the hormone’s role beyond glucose regulation and may help inform the interpretation of the diverse effects associated with emerging GIP receptor-based therapies.