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Impact of circadian disruption on glucose metabolism: implications for type 2 diabetes – published online 08/01/2020

Figure from Mason paper

Ivy C. Mason, Jingyi Qian, Gail K. Adler, Frank A. J. L. Scheer

In this issue, Mason et al (https://doi.org/10.1007/s00125-019-05059-6) provide an overview of the influence of the endogenous circadian system and its disruption on glucose control in healthy individuals and individuals with type 2 diabetes. The circadian system, a multi-oscillator system composed of the suprachiasmatic nucleus and peripheral clocks, generates endogenous 24 h rhythms in physiological functions and biological processes. The authors explain that, in healthy individuals, circadian rhythms in glucose control have been well established. However, while diurnal rhythms of glucose control in individuals with type 2 diabetes are well documented under regular sleep cycles, future studies are required to determine endogenous circadian contributions in this population. Furthermore, disruption of circadian organisation results in dysglycaemia, with converging evidence derived from epidemiological, genetic and experimental studies, although experimental and longer-term randomised controlled trials in individuals with type 2 diabetes are lacking. According to the authors, the available evidence indicates that, in healthy individuals and in those with type 2 diabetes, glycaemic control may be improved by appropriately aligning endogenous, environmental and behavioural rhythms. The figures from this review are available as a downloadable slideset.

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