Impaired postprandial skeletal muscle vascular responses to a mixed meal challenge in normoglycaemic people with a parent with type 2 diabetes – published online 29/09/2021

Ryan D. Russell, Katherine M. Roberts-Thomson, Donghua Hu, Timothy Greenaway, Andrew C. Betik, Lewan Parker, James E. Sharman, Stephen M. Richards, Stephen Rattigan, Dino Premilovac, Glenn D. Wadley, Michelle A. Keske

Blood flow increases in skeletal muscle after a mixed nutrient meal to promote nutrient storage. In individuals who are obese or have type 2 diabetes, this vascular response is impaired. However, it is unclear if this vascular impairment is present in apparently healthy people at risk of type 2 diabetes. In this issue, Russell and Roberts-Thomson et al (https://doi.org/10.1007/s00125-021-05572-7) reported that people with normal glucose tolerance but with at least one first-degree relative with type 2 diabetes have impaired skeletal muscle vascular responses to a mixed nutrient meal compared with individuals without a family history. The authors suggest that the impaired postprandial skeletal muscle vascular response is an early feature of insulin resistance. The authors conclude that these findings indicate that the skeletal muscle vasculature may be a therapeutic target for early intervention to prevent development of type 2 diabetes.

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