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Live-born children after assisted reproduction in women with type 1 diabetes and type 2 diabetes: a nationwide cohort study – published online 16/06/2020

Michael Due Larsen, Dorte Møller Jensen, Jens Fedder, Line Riis Jølving, Bente Mertz Nørgård

Type 1 and type 2 diabetes are among the most common chronic diseases in women during the fertile years and previous studies have indicated that women with diabetes have difficulty conceiving compared with reference populations. However, the efficacy of assisted reproductive technology (ART) in women with diabetes has never been studied. In this issue, Larsen and colleagues (https://doi.org/10.1007/s00125-020-05193-6) report the results of a nationwide study of 594 women with either type 1 or type 2 diabetes in the Danish ART Registry, between 2006 and 2017. The authors found that women with type 2 diabetes have a decreased chance of live birth per embryo transfer compared with women without diabetes. Furthermore, the results suggested that the decrease is related to a lower chance of implantation of the embryo. Women with type 1 diabetes had an equivalent chance of a live birth per embryo transfer as women without diabetes. The findings in women with type 2 diabetes did not seem to be driven by obesity as the same pattern was seen in both normal-weight and obese women. The authors conclude that their findings should provide reassurance for women with type 1 diabetes considering ART treatment but that prospective studies need to be performed to confirm the findings for women with types 2 diabetes in other settings and to investigate the underlying mechanisms.

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