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NAD+ metabolism as a target for metabolic health: have we found the silver bullet? – published online 16/02/2019

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Niels J. Connell, Riekelt H. Houtkooper, Patrick Schrauwen

Targeting NAD+ metabolism to improve metabolic health through sirtuin activation is a possible avenue for new therapeutic approaches to treat metabolic disorders. In this issue, Connell et al (https://doi.org/10.1007/s00125-019-4831-3) review the advances in and approaches undertaken for targeting  NAD+ metabolism in humans and their effects on human metabolism. Preclinical models have demonstrated promising results of metabolic improvement by influencing NAD+ metabolism. The transition from the preclinical to the clinical setting has proven more ambiguous and results seen in preclinical models are yet to be replicated in humans. The targeting of NAD+ metabolism in humans remains promising for improving metabolic health but warrants further exploration. The figures from this review are available as a downloadable slideset.

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