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Physical activity attenuates postprandial hyperglycaemia in homozygous TBC1D4 loss-of-function mutation carriers – published online 29/04/2021

Schnurr graphical abstract

Theresia M. Schnurr, Emil Jørsboe, Alexandra Chadt, Inger K. Dahl-Petersen, Jonas M. Kristensen, Jørgen F. P. Wojtaszewski, Christian Springer, Peter Bjerregaard, Søren Brage, Oluf Pedersen, Ida Moltke, Niels Grarup, Hadi Al-Hasani, Anders Albrechtsen, Marit E. Jørgensen, Torben Hansen

Around four per cent of the Greenlandic population carry two copies of a skeletal muscle specific TBC1D4 loss-of-function variant, which limits their ability to control their postprandial blood glucose levels and increases their risk of type 2 diabetes. In this issue, Schnurr, Jørsboe et al (https://doi.org/10.1007/s00125-021-05461-z) evaluated whether physical activity can help carriers with the loss-of-function mutation to control their blood glucose levels. They discovered that carriers with two copies of the loss-of-function mutation merely needed to carry out moderate daily physical activity to reduce glucose levels to only slightly elevated levels. In a real-life setting, this equates to one hour of hiking with hunting gear. Given the high prevalence of the loss-of-function TBC1D4 variant in the Inuit Arctic population, these findings open the door to lifestyle precision medicine and present a positive outlook for thousands of individuals with type 2 diabetes across the Arctic region.

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