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Predicting renal disease progression in a large contemporary cohort with type 1 diabetes mellitus – published online 05/12/2019

Figure from Colombo paper

Marco Colombo, Stuart J. McGurnaghan, Samira Bell, Finlay MacKenzie, Alan W. Patrick, John R. Petrie, John A. McKnight, Sandra MacRury, Jamie Traynor, Wendy Metcalfe, Paul M. McKeigue, Helen M. Colhoun, on behalf of the Scottish Diabetes Research Network (SDRN) Type 1 Bioresource Investigators and the Scottish Renal Registry

Kidney disease is a major cause of loss of quality and length of life in type 1 diabetes. Improvements in diabetes care should be reducing this complication but there are few large incidence studies in type 1 diabetes to confirm whether this is the case. Furthermore, we know that some people seem to be more susceptible to this complication than others but how to predict those most at risk is unclear. Accordingly, in this issue, Colombo et al (https://doi.org/10.1007/s00125-019-05052-z) quantified the extent to which kidney disease occurs in a large nationally representative cohort of people with type 1 diabetes and attempted to maximise prediction of kidney disease progression. The authors found that current rates of kidney disease are much lower than in historical reports and that the majority of people with type 1 diabetes have fairly stable kidney function. However, there remains a small proportion who develop this complication quickly, as well as having more cardiovascular and retinal disease, and the early identification of these individuals is challenging.

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