Shared and distinct metabolomics profiles associated with microvascular complications in the Diabetes Prevention Program Outcomes Study – Published online 11/10/2025

Wei Perng, Shiyu Shu, David M. Nathan, Jose A. Luchsinger, Robert E. Gerszten, Roeland J. W. Middelbeek, Steven E. Kahn, William C. Knowler, Dana Dabelea, Marinella Temprosa, on behalf of the DPP Research Group

Metabolomics profiling can reveal novel biomarkers of disease risk while also providing insights into the underlying mechanisms. In this study, Perng et al (https://doi.org/10.1007/s00125-025-06571-8) leveraged data from the Diabetes Prevention Project Outcomes Study (DPPOS) to characterise shared and distinct metabolite biomarkers of neuropathy, nephropathy and retinopathy—three diabetes-associated microvascular complications that are assumed to result from hyperglycaemia but also have distinct pathophysiological underpinnings—assessed after 15 years’ follow up. The authors found greater evidence of distinct, as opposed to shared, mechanisms, highlighting a need for tailored strategies to manage and prevent microvascular complications among high-risk individuals.

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