Follow us on twitter

Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity -published online 03/12/2019

Fig from Oshima paper

Masaya Oshima, Séverine Pechberty, Lara Bellini, Sven O. Göpel, Mélanie Campana, Claude Rouch, Julien Dairou, Cristina Cosentino, Federica Fantuzzi, Sanna Toivonen, Piero Marchetti, Christophe Magnan, Miriam Cnop, Hervé Le Stunff, Raphaël Scharfmann 

Rodent beta cells are highly sensitive to treatment with saturated NEFA, leading to their impairment and death. However, translating data from rodent to human beta cells remains challenging. Previous data indicate that treatment of a recently engineered functional beta cell line, EndoC-βH1, with palmitate does not induce lipotoxicity under standard culture conditions. In this issue, Oshima et al ( report that, upon stearoyl CoA desaturase (SCD) knockdown, EndoC-βH1 cells are sensitive to lipotoxicity and that they dedifferentiate. Treatment with long chain saturated NEFA exacerbates dedifferentiation and induces markers of inflammation and endoplasmic reticulum stress. The authors suggest that characterising the factors that govern SCD activity may lead to new approaches to overcome pancreatic beta cell dedifferentiation, dysfunction and apoptosis during type 2 diabetes.

All News