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Three weeks of time-restricted eating improves glucose homeostasis in adults with type 2 diabetes but does not improve insulin sensitivity: a randomised crossover trial – published online 25/07/2022

Andriessen graphical abstract

Charlotte Andriessen, Ciarán E. Fealy, Anna Veelen, Sten M. M. van Beek, Kay H. M. Roumans, Niels J. Connell, Julian Mevenkamp, Esther Moonen-Kornips, Bas Havekes, Vera B. Schrauwen-Hinderling, Joris Hoeks, Patrick Schrauwen

Time-restricted eating (TRE) is a form of intermittent fasting whereby food intake is limited to a pre-defined time window during the day. Previous studies in healthy, overweight/obese adults showed that 6–8 h TRE regimes were successful in improving metabolic health. In this issue, Andriessen et al ( investigated the effect of a more accessible 10 h TRE intervention in adults with type 2 diabetes. Three weeks of TRE resulted in lower fasting glucose and 24 h glucose levels, as well as more time spent in the normal glucose range as compared with spreading habitual food intake over at least 14 h per day. The study did not find changes in insulin sensitivity, hepatic glycogen or substrate oxidation. The authors conclude that these findings highlight the therapeutic potential of TRE in adults with type 2 diabetes. They recommend that more studies are conducted to investigate the underlying mechanisms and long-term effects of TRE.

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