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Type 2 diabetes and succinate: unmasking an age‑old molecule – published online 05/01/2024

Fernandez-Veledo graphical abstract

Sonia Fernandez‑Veledo, Anna Marsal‑Beltran, Joan Vendrell

Succinate, traditionally associated with the tricarboxylic acid (TCA) cycle, has now emerged as a key player in cellular signalling via its receptor, succinate receptor 1 (SUCNR1). In this issue, Fernández-Veledo et al (https://doi.org/10.1007/s00125-023-06063-7) explore the role of succinate in diabetes, shedding light on its evolution from a conventional intracellular metabolite to a potent extracellular signalling molecule. Succinate’s multifaceted nature, with origins in both mitochondria and the microbiome, opens doors to understanding and managing complex metabolic diseases such as diabetes. Recent insights into succinate’s biology highlight its potential as both a biomarker in and a therapeutic target for managing diabetes and its related complications, presenting exciting prospects for future research and clinical interventions. The figure from this review is available as a downloadable slide.

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