Nic has had roles in genetic association studies for BMI, overweight and obesity, birthweight, lipid profile, adiponectin, bone health, cortisol, thyroid function, allergic sensitization, educational attainment, and pigmentation. Alongside this, assessment of the causal impact of body mass index (BMI) on important health outcomes, such as ischaemic heart disease (PLoS Med 2012) has been a key focus. Work to date has included the development of methods capable of interrogating networks of cross-linked epidemiological relationships (IJO 2011, Circulation Research 2015) and the and the application of similar analysis of causal effects for thyroid, uric acid, vitamin-D, vitamin-C and had key roles in studies on interleukin 6 (relevant for drug repositioning) and statins (relevant for long term drug effects).
As a result of continuing to develop approaches to inform causality in complex networks of association, he has developed a MRC programme focused on the development and application of Recall by Genotype studies. Along with this, he co-leads a work package within the CRUK Integrative Cancer Epidemiology Programme, the newly supported NIHR BRC in Bristol and is a Wellcome Trust investigator focusing on the aetiology of BMI driven health outcomes.Back to Editorial Board