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The Pancreas in Health and in Diabetes

This year’s special issue puts the spotlight on the pancreas and its role in health and in diabetes.  With discussions on the anatomy of the whole pancreas to the role of the individual cellular components and their intra- and intercellular interactions, this series of reviews aims to provide an in-depth overview of what we know about this important organ and what we are yet to discover. Topics include: insulin production and diabetes-associated abnormalities; beta cells as autoimmune targets; functional changes in the ageing beta cell; pancreas/islet/beta cell transplant strategies; alpha cell–beta cell communication; the islet microenvironment and endocrine cell function; central nervous system control of the endocrine pancreas; and approaches to connect molecular profiles with functional properties underlying insulin secretion.

The pancreas in health and in diabetes

Sally M. Marshall
Atkinson GA

Organisation of the human pancreas in health and in diabetes

Mark A. Atkinson, Martha Campbell-Thompson, Irina Kusmartseva & Klaus H. Kaestner
Jennings GA

Transcription factors that shape the mammalian pancreas

Rachel E. Jennings, Raphael Scharfmann & Willem Staels
Vasiljevic GA

The making of insulin in health and disease

Jovana Vasiljević, Juha M. Torkko, Klaus-Peter Knoch & Michele Solimena
Rutter GA

Metabolic and functional specialisations of the pancreatic beta cell: gene disallowance, mitochondrial metabolism and intercellular connectivity

Guy A. Rutter, Eleni Georgiadou, Aida Martinez-Sanchez & Timothy J. Pullen
Mallone GA

Presumption of innocence for beta cells: why are they vulnerable autoimmune targets in type 1 diabetes?

Roberto Mallone & Decio L. Eizirik
Esser GA

Early beta cell dysfunction vs insulin hypersecretion as the primary event in the pathogenesis of dysglycaemia

Nathalie Esser, Kristina M. Utzschneider & Steven E. Kahn
Aguayo-Mazzucato GA

Functional changes in beta cells during ageing and senescence

Cristina Aguayo-Mazzucato
Rickels GA

A tale of two pancreases: exocrine pathology and endocrine dysfunction

Michael R. Rickels, Andrew W. Norris & Rebecca L. Hull
Redondo GA

The clinical consequences of heterogeneity within and between different diabetes types

Maria J. Redondo, William A. Hagopian, Richard Oram, Andrea K. Steck, Kendra Vehik, Michael Weedon, Ashok Balasubramanyam & Dana Dabelea
Bellin GA

Transplant strategies for type 1 diabetes: whole pancreas, islet and porcine beta cell therapies

Melena D. Bellin & Ty B. Dunn
Huising GA

Paracrine regulation of insulin secretion

Mark O. Huising
Moede GA

Alpha cell regulation of beta cell function

Tilo Moede, Ingo B. Leibiger & Per-Olof Berggren
Almaca GA

Beta cell dysfunction in diabetes: the islet microenvironment as an unusual suspect

Joana Almaça, Alejandro Caicedo & Limor Landsman
Faber GA

CNS control of the endocrine pancreas

Chelsea L. Faber, Jennifer D. Deem, Carlos A. Campos, Gerald J. Taborsky Jr. & Gregory J. Morton
Arrojo e Drigo GA

Molecular and functional profiling of human islets: from heterogeneity to human phenotypes

Rafael Arrojo e Drigo, Birbickram Roy & Patrick E. MacDonald
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