Then and Now
To celebrate Diabetologia’s rich history we commissioned a series of articles featuring one or more highly cited classic papers from the archives of our journal. The authors of these commentaries were invited to describe the major findings of these papers and to assess their impact on the field today. This diverse and interesting series was called Then and Now.

Deconstructing obesity: the face of fatness before and after the discovery of leptin
B. E. Grayson, R. J. Seeley
Innate immunity, insulin resistance and type 2 diabetes
J. M. Fernández-Real, J. C. Pickup
What's new since Hippocrates? Preventing type 2 diabetes by physical exercise and diet
J. A. Hawley, M. J. Gibala
How the immunoassay transformed C-peptide from a duckling into a swan
J. Roth, I. Whitford, R. Dankner, A. L. Szulc
Descriptive epidemiology of type 1 diabetes-is it still in?
M. Knip
Endothelial dysfunction in type 2 diabetes
A. Natali, E. Ferrannini
The incretin hormones: from scientific discovery to practical therapeutics
S. Mudaliar, R. R. Henry
The thrifty phenotype hypothesis revisited
A. A. Vaag, L. G. Grunnet, G. P. Arora, C. Brøns
Diabetic nephropathy in type 1 diabetes: has the outlook improved since the 1980s?
S. M. Marshall
Revisiting the connection between intramyocellular lipids and insulin resistance: a long and winding road
D. M. Muoio
Estimating insulin sensitivity and beta cell function: perspectives from the modern pandemics of obesity and type 2 diabetes
J. J. Nolan, K. Færch